치의학전문대학원

학사: 부산대학교 자연과학대학 분자생물학과
석사: 부산대학교 일반대학원 분자생물학과
박사: 부산대학교 일반대학원 분자생물학과

1998-2002: Postdoctoral Fellow, Institute for Virus Research, Kyoto University, JAPAN
● 2002-2003: Postdoctoral Fellow, National Institute of Neurological Disorders and Stroke (NINDS), NIH, USA
● 2003-2004: 선임연구원, 한국생명공학연구원 (Senior Researcher, Korea Research Institute of Bioscience & Biotechnology)
● 2004-2008: 조교수, 부산대학교 의학전문대학원 (Assistant Professor, School of Medicine, Pusan National University)
● 2008-2010: 부교수, 부산대학교 의학전문대학원 (Associate Professor, School of Medicine, Pusan National University)
● 2010-현재: 부교수, 부산대학교 치의학전문대학원 (Associate Professor, School of Dentistry, Pusan National University)

전문연구분야
혈관분자생리학

주요논문
The effect of methanol on the structural parameters of neuronal membrane lipid bilayers. Joo HJ, Ahn SH, Lee HR, Jung SW, Choi CW, Kim MS, Bae MK, Chung IK, Bae SK , Jang HO, Yun I. Korean J Physiol Pharmacol. 2012 Aug;16(4):255-64.

● Upregulation of thromboxane synthase mediates visfatin-induced interleukin-8 expression and angiogenic activity in endothelial cells. Kim SR, Jung YH, Park HJ, Kim MK, Jeong JW, Jang HO, Yun I, Bae SK , Bae MK. Biochem Biophys Res Commun. 2012 Feb 24;418(4):662-8.

● Curcumin down-regulates visfatin expression and inhibits breast cancer cell invasion. Kim SR, Park HJ, Bae YH, Ahn SC, Wee HJ, Yun I, Jang HO, Bae MK, Bae SK . Endocrinology. 2012 Feb;153(2):554-63.

● Neuromedin B receptor antagonist suppresses tumor angiogenesis and tumor growth in vitro and in vivo. Park HJ, Kim SR, Kim MK, Choi KS, Jang HO, Yun I, Bae SK , Bae MK. Cancer Lett. 2011 Dec 15;312(1):117-27.

● Visfatin induces neurite outgrowth in PC12 cells via ERK1/2 signaling pathway. Kang YS, Bae MK , Kim JY, Jeong JW, Yun I, Jang HO, Bae SK . Neurosci Lett. 2011 Oct 24;504(2):121-6.

● Effects of Curcumin on Growth Inhibition and Visfatin Expression in Human Breast Cancer Cells. Yong-Gyu Kang, Su-Ryun Kim, Moon-Kyoung Bae, Il Yoon, Hyr-Ock Jang, Soo-Kyung Bae . Cancer Prevention Research. 2011. Jun. 16 (2): 110-117.

● The lipopolysaccharide from Porphyromonas gingivalis induces vascular permeability. Kim SR, Jeong SK, Kim WS, Jeon HJ, Park HJ, Kim MK, Jang HO, Bae SK , Bae MK. International Journal of Oral Biology. 2011. March. 36(1):23-29.

● Notch1 mediates visfatin-induced FGF-2 up-regulation and endothelial angiogenesis. Bae YH, Park HJ, Kim SR, Kim JY, Kang Y, Kim JA, Wee HJ, Kageyama R, Jung JS, Bae MK, Bae SK . Cardiovasc Res. 2011 Feb 1;89(2):436-45.

● Angiogenic role of orexin-A via the activation of extracellular signal-regulated kinase in endothelial cells. Kim MK, Park HJ, Kim SR, Choi YK, Shin HK, Jeon JH, Jang HO, Yun I, Bae SK , Bae MK. Biochem Biophys Res Commun. 2010 Dec 3;403(1):59-65.

● The effect of tetracaine·HCl on rotational mobility of n-(9-Anthroyloxy) stearic acid in outer monolayers of neuronal and model membranes. Hyung-Jin Joo, Jong-Hyo Ryu, Chin-U Park, Sun-Il Jung, Yun-Seok Cha, Sang-Young Park, Jung-Un Park, Soon-Gun Kwon, Moon-Kyung Bae, Soo-Kyung Bae , Hye-Ock Jang, Il Yun. International Journal of Oral Biology 2010 Dec 35, 4, 159-167

● The effect of dimiristoylphosphatidylethanol on the rotational mobility of n-(9-Anthroyloxy) stearic acid in neuronal and model membranes. Young-Sik Park, No-Soo Park, Jun-Bong Seo, Soo-Kyung Bae , You-Kwang kim, Ki-Soo Seong, Young-Jun Kim, Ju-Won Park, Joung-Moung Shin, Young-Chan Jeon, In-Kyo Chung, Moon-Kyoung Bae, Hye-Ock Jang, Il Yun. Journal of Biophysical Chemistry, 2010 Nov 1, 3, 133-140

● Thromboxane A(2) increases endothelial permeability through upregulation of interl eukin-8. Kim SR, Bae SK , Park HJ, Kim MK, Kim K, Park SY, Jang HO, Yun I, Kim YJ, Yoo MA, Bae MK. Biochem Biophys Res Commun. 2010 Jul 2;397(3):413-9.

● Visfatin through STAT3 activation enhances IL-6 expression that promotes endothelial angiogenesis. Kim JY, Bae YH, Bae MK, Kim SR, Park HJ, Wee HJ, Bae SK . Biochim Biophys Acta. 2009 Nov;1793(11):1759-67

● Neuromedin B induces angiogenesis via activation of ERK and Akt in endothelial cells. Park HJ, Kim SR, Bae SK , Choi YK, Bae YH, Kim EC, Kim WJ, Jang HO, Yun I, Kim YM, Bae MK. Exp Cell Res. 2009 Nov 15;315(19):3359-69.

● Aspirin induces apoptosis through the blockade of IL-6-STAT3 signaling pathway in human glioblastoma A172 cells. Kim SR, Bae MK, Kim JY, Wee HJ, Yoo MA, Bae SK . Biochem Biophys Res Commun. 2009 Sep 18;387(2):342-7

● Expression of Stromal Derived Factor-1 is Upregulated in Macrophages during Thymic Regeneration in Adult Rat. Park HJ, Kim JG, Yoon S, Bae MK, Bae SK . Journal of Life Science. 2009 Sep ;19(8)1067-1072

● Resveratrol inhibits Porphyromonas gingivalis lipopolysaccharide-induced endothelial adhesion molecule expression by suppressing NF-kappaB activation. Park HJ, Jeong SK, Kim SR, Bae SK , Kim WS, Jin SD, Koo TH, Jang HO, Yun I, Kim KW, Bae MK. Arch Pharm Res. 2009 Apr;32(4):583-91

● Upregulation of fibroblast growth factor-2 by visfatin that promotes endothelial angiogenesis. Bae YH, Bae MK, Kim SR, Lee JH, Wee HJ, Bae SK . Biochem Biophys Res Commun. 2009 Feb 6;379(2):206-11.

● Porphyromonas gingivalis lipopolysaccharide increases monocyte adhesion to microvascular endothelium by induction of adhesion molecules. Kim SR, Park HJ, Bae SK, Park JH, Kim HS, Koo TH, Bae MK. International Journal of Oral Biology. 2008 Dec;33(4)149-154.

● Clotrimazole ameliorates intestinal inflammation and abnormal angiogenesis by inhibiting interleukin-8 expression through a nuclear factor-kappaB-dependent manner. Thapa D, Lee JS, Park SY, Bae YH, Bae SK , Kwon JB, Kim KJ, Kwak MK, Park YJ, Choi HG, Kim JA. J Pharmacol Exp Ther. 2008 Nov;327(2):353-64

● Age-related upregulation of Drosophila caudal gene via NF-kappaB in the adult posterior midgut. Choi YJ, Hwang MS, Park JS, Bae SK , Kim YS, Yoo MA. Biochim Biophys Acta. 2008 Oct;1780(10):1093-100.

● Visfatin enhances ICAM-1 and VCAM-1 expression through ROS-dependent NF-kappaB activation in endothelial cells. Kim SR, Bae YH, Bae SK , Choi KS, Yoon KH, Koo TH, Jang HO, Yun I, Kim KW, Kwon YG, Yoo MA, Bae MK. Biochim Biophys Acta. 2008 May;1783(5):886-95

● Wnt7b is upregulated in macrophages during thymic regeneration and negatively regulated by RANKL. Jong-Gab Kim, Sung-Min Kim, Bong-Seon Kim, Jae-Bong Kim, Sik Yoon, and Soo-Kyung Bae Journal of Life Science. 2007 17(7):923-930.

● Expression of nerve growth factor is upregulated in the rat thymic epithelial cells during thymus regeneration following acute thymic involution. Lee HW, Kim SM, Shim NR, Bae SK , Jung IG, Kwak JY, Kim BS, Kim JB, Moon JO, Chung JS, Yoon S. Regulatory Peptides. 2007 141(1-3):86-95.

● Up-regulation of VEGF expression by NGF that enhances reparative angiogenesis during thymic regeneration in adult rat. Park HJ, Kim MN, Kim JG, Bae YH, Bae MK, Wee HJ, Kim TW, Kim BS, Kim JB, Bae SK , Yoon S. Biochim Biophys Acta. 2007 Sep;1773(9):1462-72.

● Visfatin promotes angiogenesis by activation of extracellular signal-regulated kinase 1/2. Kim SR, Bae SK , Choi KS, Park SY, Jun HO, Lee JY, Jang HO, Yun I, Yoon KH, Kim YJ, Yoo MA, Kim KW, Bae MK. Biochem Biophys Res Commun. 2007 May 25;357(1):150-6

● Porphyromonas gingivalis, periodontal pathogen, lipopolysaccharide induces angiogenesis via extracellular signal-regulated kinase 1/2 activation in human vascular endothelial cells. Koo TH, Jun HO, Bae SK , Kim SR, Moon CP, Jeong SK, Kim WS, Kim GC, Jang HO, Yun I, Kim KW, Bae MK. Arch Pharm Res. 2007 Jan;30(1):34-42.

● Combined treatment of Trichostatin A and heat shock increases apoptosis in STAT3-dependent astrocytoma cells Sun-Yong Baek, Su-Ryun Kim, Moon-Kyoung Bae, Hee-Jun Wee, Yung Hyun Choi, SaeOck Oh, Bong-Seon Kim, Sik-Yoon, Soo-Kyung Bae . Cancer Prevention Research. 2006 11(3): 205-210.

● Notch signalling regulates stem cell numbers in vitro and in vivo. Androutsellis-Theotokis A, Leker RR, Soldner F, Hoeppner DJ, Ravin R, Poser SW, Rueger MA, Bae SK , Kittappa R, McKay RD. Nature. 2006 Aug 17;442(7104):823-6

● Hypoxic induction of human visfatin gene is directly mediated by hypoxia-inducible factor-1. Bae SK , Kim SR, Kim JG, Kim JY, Koo TH, Jang HO, Yun I, Yoo MA, Bae MK. FEBS Lett. 2006 Jul 24;580(17):4105-13.

● Curcumin inhibits hypoxia-induced angiogenesis via down-regulation of HIF-1. Bae MK, Kim SH, Jeong JW, Lee YM, Kim HS, Kim SR, Yun I, Bae SK , Kim KW. Oncol Rep. 2006 Jun;15(6):1557-62.

● Aspirin-induced blockade of NF-kappaB activity restrains up-regulation of glial fibrillary acidic protein in human astroglial cells. Bae MK, Kim SR, Lee HJ, Wee HJ, Yoo MA, Ock Oh S, Baek SY, Kim BS, Kim JB, Sik-Yoon, Bae SK . Biochim Biophys Acta. 2006 Mar;1763(3):282-9.

● Trichostatin A increases the thermosensitivity of human glioblastoma A172 cells. Baek SY, Kim SR, Bae MK, Hwang JW, Kim JS, Choi YH, Wee HJ, Kim BS, Kim JB, Yoon S, Bae SK . Neurosci Lett. 2006 Apr 3;396(3):230-4. Epub 2005 Dec 27

● Tid-1 interacts with the von Hippel-Lindau protein and modulates angiogenesis by destabilization of HIF-1alpha. Bae MK, Jeong JW, Kim SH, Kim SY, Kang HJ, Kim DM, Bae SK , Yun I, Trentin GA, Rozakis-Adcock M, Kim KW. Cancer Res. 2005 Apr 1;65(7):2520-5.

● Tg737 oprk 생쥐에서 배쪽신경관의 형태발생. 오세옥, 배수경 , 윤식, 백선용, 김봉선, 김재봉. (2005) 대한해부학회지 . 38(1): 73-81.

● 등쪽신경관에서 Gli3의 역할. 오세옥, 배수경 , 윤식, 백선용, 김봉선, 김재봉. (2005) , 대한해부학회지 . 38(1): 83-91.

● 발생 중 척수 전구세포영역 확립에 있어 Gli3의 역할. 오세옥, 배수경 , 윤식, 백선용, 김봉선, 김재봉 (2005) , 대한해부학회지 . 38(1): 93-102.

● Shh -/- ;Gli3 -/- 생쥐에서 뼈형태형성단백질 대항단백질의 발현. 오세옥, 문용석, 배수경 , 윤식, 백선용, 김봉선, 김재봉. (2005) 대한체질인류학회지 . 18(1): 57-68.

● 흰쥐 가슴샘 재생 과정에서 RANKL의 발현 특성. 윤식, 유현정, 김봉선, 김재봉, 배수경 . (2004) 부산대학교병원 학술지 16: 585-601

● Regulation of Egr-1 by association with the proteasome component C8. Bae MH, Jeong CH, Kim SH, Bae MK, Jeong JW, Ahn MY, Bae SK , Kim ND, Kim CW, Kim KR, Kim KW. Biochim Biophys Acta. 2002 Oct 21;1592(2):163-7.

● Jab1 interacts directly with HIF-1alpha and regulates its stability. Bae MK, Ahn MY, Jeong JW, Bae MH, Lee YM, Bae SK , Park JW, Kim KR, Kim KW. J Biol Chem. 2002 Jan 4;277(1):9-12.

● Math6, a bHLH gene expressed in the developing nervous system, regulates neuronal versus glial differentiation. Inoue C, Bae SK , Takatsuka K, Inoue T, Bessho Y, Kageyama R. Genes Cells. 2001 Nov;6(11):977-86.

● The basic helix-loop-helix gene hesr2 promotes gliogenesis in mouse retina. Satow T, Bae SK , Inoue T, Inoue C, Miyoshi G, Tomita K, Bessho Y, Hashimoto N, Kageyama R. J Neurosci. 2001 Feb 15;21(4):1265-73.

● Determination of hypoxic region by hypoxia marker in developing mouse embryos in vivo: a possible signal for vessel development. Lee YM, Jeong CH, Koo SY, Son MJ, Song HS, Bae SK , Raleigh JA, Chung HY, Yoo MA, Kim KW. Dev Dyn. 2001 Feb;220(2):175-86.

● The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation. Bae S , Bessho Y, Hojo M, Kageyama R. Development. 2000 Jul;127(13):2933-43.

● Human hepatitis B virus X protein is a possible mediator of hypoxia-induced angiogenesis in hepatocarcinogenesis. Lee SW, Lee YM, Bae SK , Murakami S, Yun Y, Kim KW. Biochem Biophys Res Commun. 2000 Feb 16;268(2):456-61.

● Identification of angiogenic properties of insulin-like growth factor II in in vitro angiogenesis models. Lee OH, Bae SK , Bae MH, Lee YM, Moon EJ, Cha HJ, Kwon YG, Kim KW. Br J Cancer. 2000 Jan;82(2):385-91.

● Egr-1 mediates transcriptional activation of IGF-II gene in response to hypoxia. Bae SK , Bae MH, Ahn MY, Son MJ, Lee YM, Bae MK, Lee OH, Park BC, Kim KW. Cancer Res. 1999 Dec 1;59(23):5989-94.

● Insulin-like growth factor II (IGF-II) secreted from HepG2 human hepatocellular carcinoma cells shows angiogenic activity. Bae MH, Lee MJ, Bae SK , Lee OH, Lee YM, Park BC, Kim KW. Cancer Lett. 1998 Jun 5;128(1):41-6.

● Hypoxia-induced apoptosis in human hepatocellular carcinoma cells: a possible involvement of the 6-TG-sensitive protein kinase(s)-dependent signaling pathway. Bae SK , Baek JH, Lee YM, Lee OH, Kim KW. Cancer Lett. 1998 Apr 10;126(1):97-104.

● Identification of genes differentially expressed by hypoxia in hepatocellular carcinoma cells. Bae MK, Kwon YW, Kim MS, Bae SK , Bae MH, Lee YM, Kim YJ, Kim KW. Biochem Biophys Res Commun. 1998 Feb 4;243(1):158-62

● Insulin-like growth factor II induced by hypoxia may contribute to angiogenesis of human hepatocellular carcinoma. Kim KW, Bae SK , Lee OH, Bae MH, Lee MJ, Park BC. Cancer Res. 1998 Jan 15;58(2):348-51.

● Anti-invasive activity of ursolic acid correlates with the reduced expression of matrix metalloproteinase-9 (MMP-9) in HT1080 human fibrosarcoma cells. Cha HJ, Bae SK , Lee HY, Lee OH, Sato H, Seiki M, Park BC, Kim KW. Cancer Res. 1996 May 15;56(10):2281-4.