치의학전문대학원

부산대학교 자연과학대학 분자생물학 학사
서울대학교 치과대학 두개악안면 생리학 박사

서울대학교 치과대학, Bone Metabolism Research Center (책임연구원)
경희대학교 치과대학, Tooth and Periodontal Tissue Regeneration Center (학술연구교수)

International Journal of Oral Biology 공로상 (최다인용 부문, 2020)

대한골대사학회 구강악안면 연구위원회 위원
부산과학기술기획평가원 BMS 포럼 위원
국제치과연구학회 한국지부회 정책이사
대한구강생물학회 홍보이사
대한기초치의학협의회 공보이사

Research Interest
Osteoclast and osteoblast biology
Molecular mechanisms of bone metastasis
Cell therapeutic application of dental stem cells for bone regeneration
Organoid based tooth regeneration

Selected Publications
Vasohibin-1 promotes osteoclast differentiation in periodontal disease by stimulating the expression of RANKL in gingival fibroblasts. Soon Chul Heo, Yu Na Kim, Bo Ram Keum, Ji-Young Joo, Moon-Kyoung Bae, Hyung Joon Kim. Biochim Biophys Acta Mol Basis Dis. 2023 Mar

Virulence factors released from Porphyromonas gingivalis induce electrophysiological dysfunction in human pluripotent stem cell-derived cardiomyocytes. Soon Chul Heo, Ye Seul Kim, Yu Na Kim, Jae Ho Kim, Hyung Joon Kim. Journal of Dental Sci. 2022 Oct

Pim-2 regulates bone resorptive activity of osteoclasts via V-ATPase a3 isoform expression in periodontal disease. Soon C Heo, Jae C You, Suhan Jung, Yu N Kim, Sang-Hun Shin, Jae-Yeol Lee, Hyung Joon Kim. J Cell Physiol. 2022 Aug

Gastrin-Releasing Peptide (GRP) Stimulates Osteoclastogenesis in Periodontitis. YunJeong Choi, Soon Chul Heo, Yu Na Kim, Ji-Young Joo, Jae Joon Hwang, Moon-Kyoung Bae, Hyung Joon Kim. Cells. 2020 Dec

Letrozole Suppresses the Fusion of Osteoclast Precursors through Inhibition of p38-Mediated DC-STAMP Pathway. Hyung Joon Kim, Hwa-Sik Seong, YunJeong Choi, Soon Chul Heo, Yong-Deok Kim. Int J Mol Sci. 2020 Nov

Evaluation of 1-Ethyl-3-(3-Dimethylaminopropyl) Carbodiimide Cross-Linked Collagen Membranes for Guided Bone Regeneration in Beagle Dogs. Jong-Ju Ahn, Hyung-Joon Kim, Eun-Bin Bae, Won-Tak Cho, YunJeong Choi, Su-Hyun Hwang, Chang-Mo Jeong, Jung-Bo Huh. Materials. 2020 Oct

Assessing the effects of cyclosporine A on the osteoblastogenesis, osteoclastogenesis, and angiogenesis mediated by human periodontal ligament stem cells. Hyun-Joo Kim, Ji Hyun Yoo, YunJeong Choi, Ji-Young Joo, Ju-Youn Lee, Hyung Joon Kim. P Periodontol. 2020 Jun

Connective tissue growth factor (CTGF) regulates the fusion of osteoclast precursors by inhibiting Bcl6 in periodontitis. YunJeong Choi, Ji Hyun Yoo, Jae-Hyung Lee, Youngkyun Lee, Moon-Kyoung Bae, Yong-Deok Kim, Hyung Joon Kim. Int J Med Sci. 2020 Feb

A CTGF-RUNX2-RANKL Axis in Breast and Prostate Cancer Cells Promotes Tumor Progression in Bone. Bongjun Kim, Haemin Kim, Suhan Jung, Aree Moon, Dong-Young Noh, Zang Hee Lee, Hyung Joon Kim, Hong-Hee Kim. J Bone Miner Res. 2020 Jan

S100A4 released from highly bone-metastatic breast cancer cells plays a critical role in osteolysis. Haemin Kim, Bongjun Kim, Sang Il Kim, Hyung Joon Kim, Brian Y Ryu, Junho Chung, Zang Hee Lee, Hong-Hee Kim. Bone Res. 2019 Sep

Comparison of Bone Regeneration between Porcine-Derived and Bovine-Derived Xenografts in Rat Calvarial Defects: A Non-Inferiority Study. Eun-Bin Bae, Ha-Jin Kim, Jong-Ju Ahn, Hyun-Young Bae, Hyung-Joon Kim, Jung-Bo Huh. Materials. 2019 Oct

A novel Bruton's tyrosine kinase inhibitor, acalabrutinib, suppresses osteoclast differentiation and Porphyromonas gingivalis lipopolysaccharide-induced alveolar bone resorption. Nitin Kumar Pokhrel, Yong-Gun Kim, Hyo Jeong Kim, Hyung Joon Kim, Ji Hye Lee, So-Young Choi, Tae-Geon Kwon, Heon-Jin Lee, Jae-Young Kim, Youngkyun Lee. J Periodontol. 2019 May

Zoledronate Enhances Osteocyte-Mediated Osteoclast Differentiation by IL-6/RANKL Axis. Hyung Joon Kim, Ha Jin Kim, YunJeong Choi, Moon-Kyoung Bae, Dae Seok Hwang, Sang-Hun Shin, Jae-Yeol Lee. Int J Mol Sci. 2019 Mar

Calcium-Phosphate Crystals Promote RANKL Expression via the Downregulation of DUSP1. YunJeong Choi, Ji Hyun Yoo, Youngkyun Lee, Moon Kyoung Bae, Hyung Joon Kim. Mol Cells. 2019 Feb

Effect of Titanium Implants Coated with Radiation-Crosslinked Collagen on Stability and Osseointegration in Rat Tibia. Eun-Bin Bae, Ji-Hyun Yoo, Sung-In Jeong, Min-Su Kim, Youn-Mook Lim, Jong-Ju Ahn, Jin-Ju Lee, So-Hyoun Lee, Hyung-Joon Kim, Jung-Bo Huh. Materials. 2018 Dec

Bortezomib prevents ovariectomy-induced osteoporosis in mice by inhibiting osteoclast differentiation. Sung-Hyun Kim, Myoung Ok Kim, Hyo Jeong Kim, Sanjiv Neupane, Hyung Joon Kim, Ji Hye Lee, Hong-Hee Kim, Jae-Young Kim, Youngkyun Lee. J Bone Miner Metab. 2018 Sep

Effect of orthodontic forces on the osteogenic differentiation of human periodontal ligament stem cells. Yoo JH, Lee SM, Bae MK, Lee DJ, Ko CC, Kim YI, Kim HJ. J Oral Sci. 2018 May

Effect of remifentanil on pre-osteoclast cell differentiation in vitro. Jeon HO, Choi IS, Yoon JY, Kim EJ, Yoon JU, Cho AR, Kim HJ, Kim CH. J Dent Anesth Pain Med. 2018 Feb

Porphyromonas gingivalis accelerates atherosclerosis through oxidation of high-density lipoprotein. Kim HJ, Cha GS, Kim HJ, Kwon EY, Lee JY, Choi J, Joo JY. J Periodontal Implant Sci. 2018 Feb

Gastrin-releasing peptide promotes the migration of vascular smooth muscle cells through upregulation of matrix metalloproteinase-2 and ?9. Park HJ, Kim MK, Kim Y, Bae SS, Kim HJ, Bae SK, Bae MK. BMB Rep. 2017 Dec

Bortezomib prevents ovariectomy-induced osteoporosis in mice by inhibiting osteoclast differentiation. Kim SH, Kim MO, Kim HJ, Neupane S, Kim HJ, Lee JH, Kim HH, Kim JY, Lee Y. J Bone Miner Metab. 2017 Oct

Transglutaminase 2 regulates osteoclast differentiation via a Blimp1-dependent pathway. Kim WS, Kim H, Jeong EM, Kim HJ, Lee ZH, Kim IG, Kim HH. Sci Rep. 2017 Sep

Suppression of Osteoclastogenesis by Melatonin: A Melatonin Receptor-Independent Action. Kim HJ, Kim HJ, Bae MK, Kim YD. Int J Mol Sci. 2017 May

Gastrin-releasing peptide induces monocyte adhesion to vascular endothelium by upregulating endothelial adhesion molecules. Kim MK, Park HJ, Kim Y, Kim HJ, Bae SK, Bae MK. Biochem Biophys Res Commun. 2017 Apr

SOD2 and Sirt3 Control Osteoclastogenesis by Regulating Mitochondrial ROS. Kim H, Lee YD, Kim HJ, Lee ZH, Kim HH. J Bone Miner Res. 2017 Feb

Elevated MicroRNA-128 in Periodontitis Mitigates Tumor Necrosis Factor-α Response via p38 Signaling Pathway in Macrophages. Na HS, Park MH, Song YR, Kim S, Kim HJ, Lee JY, Choi JI, Chung J. J Periodontol. 2016 Sep

PIN1 Suppresses the Hepatic Differentiation of Pulp Stem Cells via Wnt3a. HJ Kim, YA Cho, YM Lee, SY Lee, WJ Bae, EC Kim. J Dent Res. 2016 Nov

A novel role for flotillin-1 in H-Ras-regulated breast cancer aggressiveness. Koh M, Yong HY, Kim ES, Son H, Jeon YR, Hwang JS, Kim MO, Cha Y, Choi WS, Noh DY, Lee KM, Kim KB, Lee JS, Kim HJ, Kim H, Kim HH, Kim EJ, Park SY, Kim HS, Moon WK, Choi Kim HR,
Moon A. Int J Cancer. 2016 Mar

Bortezomib Inhibits Osteoclastogenesis and Porphyromonas gingivalis Lipopolysaccharide-induced Alveolar Bone Resorption. Y-G Kim, JH Kang, HJ Kim, HJ Kim, H-H Kim, J-Y Kim, Y Lee. J Dent Res. 2015 Sep

NOD2 Mediates Odontoblast Differentiation and RANKL Expression. SI Lee, GT Kim, HJ Kim, SH Park, EC Kim. J Dent Res. 2014 Jul

Mitogen- and stress-activated protein kinase 1 activates osteoclastogenesis in vitro and affects bone destruction in vivo. Jeongim Ha, Hyung Joon Kim, Hao Huang, Zang Hee Lee, Hong-Hee Kim. J Mol Med. 2013 Aug

Apolipoprotein E inhibits osteoclast differentiation via regulation of c-Fos, NFATc1 and NF-κB. Woo-Shin Kim, Hyung Joon Kim, Zang Hee Lee, Youngkyun Lee, Hong-Hee Kim. Exp Cell Res. 2013 Feb

Plasma membrane calcium ATPase regulates bone mass by fine-tuning osteoclast differentiation and survival. Hyung Joon Kim, Vikram Prasad, Seok-Won Hyung, Zang Hee Lee, Sang-Won Lee, Aditi Bhargava, David Pearce, Youngkyun Lee, Hong-Hee Kim. J Cell Biol. 2012 Dec