재임 교수

김태성 ( Tae Sung Kim )

직위: 조교수/이학박사

전공: 구강·병원미생물학/세포분자면역학

이메일: tskim@pusan.ac.kr

소속: 구강미생물학교실

세부내용
- 세부내용

학력

· 충남대학교 의학전문대학원 의과학과 감염면역제어전공 석,박사

경력

· 2017.09 - 2018.06 충남대학교 기초의과학연구센터 박사후연구원

· 2018.07 - 2024.10 미국 국립보건원 (NIH) 국립치의학구강안면연구소 (NIDCR) 박사후연구원

· 2024.10 - 2025.07 미국 국립보건원 (NIH) 국립알레르기감염병연구소 (NIAID) 박사후연구원

· 2025.09 - 현재 부산대학교 치의학전문대학원 구강미생물학교실 조교수

수상경력

· 2013 우수연구상, 충남대학교 의학전문대학원

· 2014 대학원연구활성화지원사업 장학금 수혜, 충남대학교

· 2014 최우수연구구연발표상, 대한미생물학회

· 2016 쎌바이오텍상(1st place), 한국미생물생명공학회

· 2017 충남대학교 총장상 (공적표창), 충남대학교

· 2023 우수연구펠로우상, NIH Fellows Award for Research Excellence (FARE), 미국 국립보건원

· 2023 신진연구자상, Annual Bioscience and Engineering Symposium, 미국 NIH-KSA 협회

· 2024 William E. Paul Award, Best Paper in cytokine research, 미국 NIH-FDA Cytokine Interest Group

주요활동

· 주요논문 - 부산대학교 연구정보시스템(PNU Scholar) 연구자 프로필

1. Kim TS*, Moutsopoulos NM. Neutrophils and Neutrophil Extracellular Traps in Oral Health and Disease. Exp Mol Med. 2024 May 1. *Correspondence

2. Kim TS, Ikeuchi T, Theofilou VI, Williams DW, Greenwell-Wild T, June A, Adade E, Li L, Abusleme L, Dutzan N, Yuan Y, Brenchley L, Bouladoux N, Sakamachi Y, NIDCD/NIDCR Genomics and Computational Biology Core, Palmer R, Iglesias-Bartolome R, Trichieri G, Garantziotis S, Belkaid Y, Valm AM, Diaz PI, Holland SM, Moutsopoulos NM. Epithelial-derived interleukin 23 promotes oral mucosal immunopathology. Immunity 2024 Apr 9;57(4):859-875.e11.

* Highlighted in “Previews” in Immunity 2024.

* The 30-year celebratory Issue of Immunity 2024.

3. Kim TS, Silva LM, Theofilou VI, Greenwell-Wild T, Li L, Williams DW, Ikeuchi T, Brenchley L; NIDCD/NIDCR Genomics and Computational Biology Core; Bugge TH, Diaz PI, Kaplan MJ, Carmona-Rivera C, Moutsopoulos NM. Neutrophil extracellular traps and extracellular histones potentiate IL-17 inflammation in periodontitis. J Exp Med 2023;4;220(9):e20221751.

* Annual Best of JEM Series.

* Highlighted in “Research highlights” in Nature Reviews Rheumatology 2023.

* Highlighted in “Insights” in J Exp Med 2023.

4. Silva LM, Kim TS, Moutsopoulos NM. Neutrophils are gatekeepers of mucosal immunity. Immunol Rev 2023 Mar;314(1):125-141.

5. Kim TS, Jin YB, Kim YS, Kim S, Kim JK, Lee HM, Suh HW, Choe JH, Kim YJ, Koo BS, Kim HN, Jung MG, Lee SH, Kim DK, Chung CU, Son JW, Min JJ, Kim JM, Deng CX, Kim HS, Lee SR, Jo EK. SIRT3 promotes antimycobacterial defenses by coordinating mitochondrial and autophagic functions. Autophagy 2019 Aug;15(8):1356-1375.

6. Kim SY, Yang C, Lee HM, Kim JK, Kim YS, Kim YR, Kim JS, Kim TS, Yuk JM, Dufour CR, Lee SH, Kim JM, Choi HS, Gigu?re V, Jo EK. ESRRA (estrogen-related receptor α) is a key coordinator of transcriptional and post-translational activation of autophagy to promote innate host defense. Autophagy 2017;25:1-17.

7. Kim TS, Choe JH, Kim YJ, Yang CS, Kwon HJ, Jeong J, Kim G, Park DE, Jo EK, Cho YL, Jang J. Activities of LCB01-0371, a novel oxazolidinone, against Mycobacterium abscessus. Antimicrob Agents Chemother 2017;3. pii: AAC.02752-16.

8. Kim TS, Shin YH, Lee HM, Kim JK, Choe JH, Jang JC, Um S, Jin HS, Komatsu M, Cha GH, Chae HJ, Oh DC, Jo EK. Ohmyungsamycins promote antimicrobial responses through autophagy activation via AMP-activated protein kinase pathway. Sci Rep 2017;13;7:3431.

9. Kim JK, Lee HM, Park KS, Shin DM, Kim TS, Kim YS, Suh HW, Kim SY, Kim IS, Kim JM, Son JW, Sohn KM, Jung SS, Chung C, Han SB, Yang CS, Jo EK. MIR144* inhibits antimicrobial responses against Mycobacterium tuberculosis in human monocytes and macrophages by targeting the autophagy protein DRAM2. Autophagy 2017;13:423-441.

10. Yuk JM, Kim TS, Kim SY, Lee HM, Han J, Dufour CR, Kim JK, Jin HS, Yang CS, Park KS, Lee CH, Kim JM, Kweon GR, Choi HS, Vanacker JM, Moore DD, Gigu?re V, Jo EK. Orphan Nuclear receptor ERRα controls macrophage metabolic signaling and A20 expression to negatively regulate TLR-Induced Inflammation. Immunity 2015;43:80-91.

11. Yang CS, Kim JJ, Kim TS, Lee PY, Kim SY, Lee HM, Shin DM, Nguyen LT, Lee MS, Jin HS, Kim KK, Lee CH, Kim MH, Park SG, Kim JM, Choi HS, Jo EK. Small heterodimer partner interacts with NLRP3 and negatively regulates activation of the NLRP3 inflammasome. Nat Commun 2015;6:6115

12. Kim TS, Kim YS, Yoo H, Park YK, Jo EK. Mycobacterium massiliense induces inflammatory responses in macrophages through Toll-like receptor 2 and c-Jun N-terminal kinase. J Clin Immunol 2014;34:212-23.

13. Kim TS, Lee HM, Hk Y, Park YK, Jo EK. Intracellular signaling pathways that regulate macrophage chemokine expression in response to Mycobacterium abscessus. J Bacteriol Virol 2012;42:121?32.

· 홈페이지 - https://lomi.pusan.ac.kr/lomi/index.do

· 특허

1. 사이클릭 펩티드 화합물을 포함한 마이코박테리움속 세균 감염증의 예방 또는 치료용 약학적 조성물 및 이를 이용한 방법 (2023)

2. PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING MYCOBACTERIUM SPECIES INFECTION AND METHOD USING THE SAME, 미국 특허 (2020)

3. PPAR-α를 포함하는 결핵 진단용 바이오마커 조성물 (2019)

4. Sirt3를 유효성분으로 하는 항결핵 약학 조성물 (2018)

5. SHP를 유효성분으로 하는 신장질환 예방 및 치료용 조성물 (2017)

· 관심연구분야

[세부전공분야]

- Oral Microbiology (구강 미생물학)

- Basic &Clinical Immunology (기초·임상 면역학)

- Mucosal Immunology (점막 면역학),